Background Retraction is a mechanism for alerting readers to unreliable material and other problems in the published scientific and scholarly record. Retracted publications generally remain visible and searchable, but the intention of retraction is to mark them as “removed” from the citable record of scholarship. However, in practice, some retracted articles continue to be treated by researchers and the public as valid content as they are often unaware of the retraction. Research over the past decade has identified a number of (...) factors contributing to the unintentional spread of retracted research. The goal of the Reducing the Inadvertent Spread of Retracted Science: Shaping a Research and Implementation Agenda (RISRS) project was to develop an actionable agenda for reducing the inadvertent spread of retracted science. This included identifying how retraction status could be more thoroughly disseminated, and determining what actions are feasible and relevant for particular stakeholders who play a role in the distribution of knowledge. -/- Methods These recommendations were developed as part of a year-long process that included a scoping review of empirical literature and successive rounds of stakeholder consultation, culminating in a three-part online workshop that brought together a diverse body of 65 stakeholders in October–November 2020 to engage in collaborative problem solving and dialogue. Stakeholders held roles such as publishers, editors, researchers, librarians, standards developers, funding program officers, and technologists and worked for institutions such as universities, governmental agencies, funding organizations, publishing houses, libraries, standards organizations, and technology providers. Workshop discussions were seeded by materials derived from stakeholder interviews (N = 47) and short original discussion pieces contributed by stakeholders. The online workshop resulted in a set of recommendations to address the complexities of retracted research throughout the scholarly communications ecosystem. -/- Results The RISRS recommendations are: (1) Develop a systematic cross-industry approach to ensure the public availability of consistent, standardized, interoperable, and timely information about retractions; (2) Recommend a taxonomy of retraction categories/classifications and corresponding retraction metadata that can be adopted by all stakeholders; (3) Develop best practices for coordinating the retraction process to enable timely, fair, unbiased outcomes; and (4) Educate stakeholders about pre- and post-publication stewardship, including retraction and correction of the scholarly record. -/- Conclusions Our stakeholder engagement study led to 4 recommendations to address inadvertent citation of retracted research, and formation of a working group to develop the Communication of Retractions, Removals, and Expressions of Concern (CORREC) Recommended Practice. Further work will be needed to determine how well retractions are currently documented, how retraction of code and datasets impacts related publications, and to identify if retraction metadata (fails to) propagate. Outcomes of all this work should lead to ensuring retracted papers are never cited without awareness of the retraction, and that, in public fora outside of science, retracted papers are not treated as valid scientific outputs. (shrink)

A background assumption of this paper is that the repertoire of inference schemes available to humanity is not fixed, but subject to change as new schemes are invented or refined and as old ones are obsolesced or abandoned. This is particularly visible in areas like health and environmental sciences, where enormous societal investment has been made in finding ways to reach more dependable conclusions. Computational modeling of argumentation, at least for the discourse in expert fields, will require the possibility of (...) modeling change in a stock of schemes that may be applied to generate conclusions from data. We examine Randomized Clinical Trial, an inference scheme established within medical science in the mid-20th Century, and show that its successful defense by means of practical reasoning allowed for its black-boxing as an inference scheme that generates (and warrants belief in) conclusions about the effects of medical treatments. Modeling the use of a scheme is well-understood; here we focus on modeling how the scheme comes to be established so that it is available for use. (shrink)

It is illegitimate to read any ontology about "race" off of biological theory or data. Indeed, the technical meaning of "genetic variation" is fluid, and there is no single theoretical agreed-upon criterion for defining and distinguishing populations (or groups or clusters) given a particular set of genetic variation data. Thus, by analyzing three formal senses of "genetic variation"—diversity, differentiation, and heterozygosity—we argue that the use of biological theory for making epistemic claims about "race" can only seem plausible when it relies (...) on the user’s own assumptions about race; the move from biological measures to claims about “race” inevitably amounts to a pernicious reification. We also excavate assumptions in the history of the technical discourse over the concept of "race" (e.g., Livingstone's and Dobzhansky's 1962 exchange, Edwards' 2003 response to Lewontin 1972, as well as contemporary discussions of cladistic "race", and "races" as clusters). We show that claims about the existence (or non-existence) of "race" are underdetermined by biological facts, methods, and theories. Biological theory does not force the concept of "race" upon us; our social discourse, social ontology, and social expectations do. We become prisoners of our abstractions at our own hands, and at our own expense. (shrink)

Bradley Armour-Garb and James A. Woodbridge, in Pretense and Pathology, make an ambitious and far-ranging case that philosophical fictionalism (particularly the pretence variety that they favour) illuminates several long-standing philosophical puzzles posed by words in ordinary language, such as ‘exist’, ‘true’ and ‘means that’, as well as the more technical, ‘refers to’, ‘proposition’ and ‘satisfies’. Along the way, Armour-Garb and Woodbridge discuss topics in the philosophy of language, philosophical logic, ontology, epistemology and more. An important aspect of their project is (...) its nominalist aspiration: by showing (if they do) that pretence is involved when we use the foregoing terms, they hope to show that it’s false that these uses induce ontological commitments (to, e.g., propositions or properties). In this respect, their pretence approach is yet another attempt to undercut the family of indispensability arguments (pioneered by W.V.O. Quine) that prima facie force ontological commitments by means of indispensable language usage. (shrink)

This paper distinguishes three concepts of "race": bio-genomic cluster/race, biological race, and social race. We map out realism, antirealism, and conventionalism about each of these, in three important historical episodes: Frank Livingstone and Theodosius Dobzhansky in 1962, A.W.F. Edwards' 2003 response to Lewontin (1972), and contemporary discourse. Semantics is especially crucial to the first episode, while normativity is central to the second. Upon inspection, each episode also reveals a variety of commitments to the metaphysics of race. We conclude by interrogating (...) the relevance of these scientific discussions for political positions and a post-racial future. (shrink)

In this thesis I develop an account of how processes of social understanding are implicated in experiences of mental disorder, critiquing the lack of examination of this phenomena along the way. First, I demonstrate how disorder concepts, as developed and deployed by psychiatric institutions, have the effect of shaping the cognition of individuals with psychopathology through setting expectations. Such expectation-setting can be harmful in some cases, I argue, and can perpetuate epistemic injustices. Having developed this view, I criticise enactive accounts (...) of mental disorder for failing to consider how such terms like ‘dysfunction’ are open to interpretation and can come embedded with normative expectations. Enactive accounts consequently run the risk of perpetuating injustices in their account of the sociality of mental disorder. Similar concerns arise when we consider the attachment of enactivism to the medical model, I argue. But by adapting enactivism to consider other experiences of disorder, such as those described as ‘madness’, enactive psychiatry may genuinely provide ethical groundwork for a better conception of disordered experience. Then, I consider a further concern with a distinctly medicalised conception of mental disorder from the perspective of self-illness ambiguity, arguing that self-illness ambiguities appear to form a special class of ambiguities due to their proximity to disorder concepts which mark them as appropriate targets for therapeutic treatment. However, I argue further that we should be critical of the idea that self-illness ambiguities necessitate disambiguation, as, in cases where self and illness are demarcated, individuals may still experience distress because simply having a mental disorder can be socially alienating. The medicalised focus in self-illness ambiguity, and the explicit need from the medical perspective to disambiguate it, might then exacerbate the distress someone experiences in mental disorder. Moreover, drawing on Mad Studies, I suggest that one might not need a coherent self-narrative to live well. Because of this, one may not need to adopt a medicalised view of the self in the case of selfillness ambiguity. In order to support this analysis, I provide a phenomenological account of language and argue that the very thoughts implicated in mental disorder shape the individual’s perception of the world due to the way that language foregrounds particular aspects of our world. This demands a critical examination of the language adopted and used by both clinicians and disordered individuals. I thus conclude with some thoughts on how to approach research and developing understanding of mental disorder given that we, as people, are always implicated in this process and therefore socialisation of some kind will always be taking place. (shrink)

Lewis et al. (2011) attempted to restore the reputation of Samuel George Morton, a 19th century physician who reported on the skull sizes of different folk-races. Whereas Gould (1978) claimed that Morton’s conclusions were invalid because they reflected unconscious bias, Lewis et al. alleged that Morton’s findings were, in fact, supported, and Gould’s analysis biased. We take strong exception to Lewis et al.’s thesis that Morton was “right.” We maintain that Gould was right to reject Morton’s analysis as inappropriate and (...) misleading, but wrong to believe that a more appropriate analysis was available. Lewis et al. fail to recognize that there is, given the dataset available, no appropriate way to answer any of the plausibly interesting questions about the “populations” in question (which in many cases are not populations in any biologically meaningful sense). We challenge the premise shared by both Gould and Lewis et al. that Morton’s confused data can be used to draw any meaningful conclusions. This, we argue, reveals the importance of properly focusing on the questions asked, rather than more narrowly on the data gathered. (shrink)

This is a story about three of my favorite philosophers—Donnellan, Russell, and Frege—about how Donnellan’s concept of having in mind relates to ideas of the others, and especially about an aspect of Donnellan’s concept that has been insufficiently discussed: how this epistemic state can be transmitted from one person to another.

Stroud has argued for many years that skepticism is conditionally correct. We cannot, he claims, both undergo a Cartesian-style examination of the extent of our knowledge as well as avoid skepticism. One reason Stroud's position appears quite plausible is the so-called "totality condition" imposed for this kind of examination: as inquiring philosophers we are called upon to assess all of our knowledge, all at once. However, in this paper I argue that Stroud's apparent understanding of the totality condition is mistaken. (...) Evidently, Stroud thinks that honoring the totality condition amounts to imposing the strong requirement that we initially assume that we don't know anything about external reality. However, there is a weaker requirement available: that we initially not assume that we know anything about external reality. I argue i) that the weaker conception of the totality condition is most suitable for the kind of philosophical examination that Stroud seems to have in mind; and ii) that according to this same conception skepticism is not conditionally correct. (shrink)

Contemporary reasoning about health is infused with the work products of experts, and expert reasoning about health itself is an active site for invention and design. Building on Toulmin’s largely undeveloped ideas on field-dependence, we argue that expert fields can develop new inference rules that, together with the backing they require, become accepted ways of drawing and defending conclusions. The new inference rules themselves function as warrants, and we introduce the term “warranting device” to refer to an assembly of the (...) rule plus whatever material, procedural, and institutional resources are required to assure its dependability. We present a case study on the Cochrane Review, a new method for synthesizing evidence across large numbers of scientific studies. After reviewing the evolution and current structure of the device, we discuss the distinctive kinds of critical questions that may be raised around Cochrane Reviews, both within the expert field and beyond. Although Toulmin’s theory of field-dependence is often criticized for its relativism, we find that, as a matter of practical fact, field-specific warrants do not enjoy immunity from external critique. On the contrary, they can be opened to evaluation and critique from any interested perspective. (shrink)

We attempt to improve the understanding of the notion of agene being `for a phenotypic trait or traits. Considering theimplicit functional ascription of one thing being `for another,we submit a more restrictive version of `gene for talk.Accordingly, genes are only to be thought of as being forphenotypic traits when good evidence is available that thepresence or prevalence of the gene in a population is the resultof natural selection on that particular trait, and that theassociation between that trait and the gene (...) in question isdemonstrably causal. It is therefore necessary to gatherstatistical, biochemical, historical, as well as ecologicalinformation before properly claiming that a gene is for aphenotypic trait. Instead of hampering practical use of the `genefor talk, our approach aims at stimulating much needed researchinto the functional ecology and comparative evolutionary biologyof gene action. (shrink)

The problem of philosophical skepticism relates to the difficulty involved in underwriting the claim that we know anything of spatio-temporal reality. It is often claimed, in fact, that proper philosophical scrutiny reveals quite the opposite from what common sense suggests. Knowledge of external reality is thought to be even quite obviously denied to us as a result of the alleged fact that we all fail to know that certain skeptical scenarios do not obtain. A skeptical scenario is one in which (...) we have neurological occurrences just like any normal situation in which we actually perceive spatio-temporal objects, but where we are deceived in some sense as a result of the manipulation of our brains from some outside source. In this work I attempt to address the problem of philosophical skepticism by claiming that most of us are able to come to know plenty about external reality, since we can come to realize that a certain philosophical theory of perception is correct. The theory I have in mind is what I call a non-cognitive theory of perception. According to this view, perceptual experience is defined by continuous, sensitive behavioral interaction with spatio-temporal objects of the appropriate size, shape, hardness, speed, etc. Knowing that this theory of perception is correct is equivalent to knowing that we know plenty about external reality. This is ultimately because by knowing that a non-cognitive theory of perception is true, we know that any skeptical scenario must fail to obtain. The structure of the work proceeds by first discussing the significance of the problem of philosophical skepticism in some detail. Chapter 1 lays out how the problem does indeed forcefully arise if it is conceded that we fail to know that the skeptical scenarios fail to obtain. Chapter 2 develops the sort of view of our epistemological situation that falls out of accepting without qualification that the problem exists. Chapter 3 examines and criticizes certain popular responses to the skeptical problem. The main goal of these first three preliminary chapters is to indicate that once it is admitted that we fail to know that the skeptical scenarios fail to obtain, the problem of philosophical skepticism forcefully presents itself. Chapter 4, however, attacks the idea that we fail to know that the skeptical scenarios fail to obtain. In this chapter I argue that this idea is wedded to the position that a certain theory of perception is correct. The theory in question is what I call a conjunctive theory of veridical experience. According to this view, normal experience of spatio-temporal objects occurs when a subject has a certain perceptual experience, and that experience also happens to match up with and/or be satisfied by what is really the case. Only when a theory of this sort is assumed, I argue, is the claim that we fail to know that the skeptical scenarios fail to obtain found to be obvious. In chapter 5 I argue that, in fact, a non-cognitive theory, rather than a conjunctive theory, is the correct view to maintain. In the final chapter 6 I develop the epistemological position that falls out of accepting a non-cognitive theory. (shrink)

I argue that conscious visual experience is essentially a non-representational demonstration of a skill. The explication and defense of this position depends on both phenomenological and empirical considerations. The central phenomenological claim is this: as a matter of human psychology, it is impossible to produce a conscious visual experience of a mind-independent object that is sufficiently like typical cases, without including concomitant proprioceptive sensations of the sort of extra-neural behavior that allows us to there and then competently detect such objects. (...) I then argue that this view, which is a version of enactivism, best explains the temporality of conscious experience—what is often called the specious present. (shrink)

This paper argues that various phenomenological considerations support a non-representational causal account of visual experience. This position claims that visual experiences serve as a non-representational causally efficacious medium for the production of beliefs concerning the external world. The arguments are centered on defending a non-representational causal account’s understanding of the cognitive significance of visual experience. Among other things, such an account can easily explain the inextricable role that background beliefs and conceptual capacities play in perceptually-based external world belief-formation processes, the (...) fact that visual mental states constrain beliefs because of their presentational phenomenology, and the phenomenon known as the transparency of visual experience. (shrink)

In the 1980s and early 1990s, the normativity of meaning was thought to be more-or-less 'incontestable.' But in the last 25 years, many philosophers of mind and language have contested it in several seemingly different ways. This, however, is somewhat illusory. There is an unappreciated commonality among most anti-normativist arguments, and this commonality, I argue, poses a problem for anti-normativism. The result, however, is not a wholesale rejection of anti-normativism. Rather, an insight from the anti-normativist position can be harnessed to (...) reveal an unappreciated position in the normativity of meaning debate. (shrink)

A singular thought can be characterized as a thought which is directed at just one object. The term ‘thought’ can apply to episodes of thinking, or to the content of the episode (what is thought). This paper argues that episodes of thinking can be just as singular, in the above sense, when they are directed at things that do not exist as when they are directed at things that do exist. In this sense, then, singular thoughts are not object-dependent.

In this article, we discuss the continued circulation and use of retracted science as a complex problem: Multiple stakeholders throughout the publishing ecosystem hold competing perceptions of this problem and its possible solutions. We describe how we used a participatory design process model to co-develop recommendations for addressing this problem with stakeholders in the Alfred P. Sloan-funded project, Reducing the Inadvertent Spread of Retracted Science (RISRS). After introducing the four core RISRS recommendations, we discuss how the issue of retraction-related stigma (...) gives rise to recommendation #4, Educate stakeholders about retraction and pre- and post-publication stewardship of the scholarly record. This recommendation is important for training publishing professionals and realizing this recommendation will require further collaborative design work across scholarly communications. We highlight ongoing stakeholder work which is now re-starting the design cycle. We conclude with a discussion of ongoing activities facilitating uptake and refinement of RISRS research and the implementation agenda. (shrink)

Many of the most important social institutions—e.g., law and language—are thought to be normative in some sense. And philosophers have been puzzled by how this normativity can be explained in terms of the social, descriptive states of affairs that presumably constitute them. This paper attempts to solve this sort of puzzle by considering a simpler and less contentious normative social practice: table manners. Once we are clear on the exact sense in which a practice is normative, we see that some (...) practices can be normative in an interesting and non-trivial sense, but also explicable with merely descriptive resources. In addition to arguing that it is possible to explain normative practices with descriptive resources, this paper presents and defends just such an explanation—an account of the nature of table manners that appeals only to descriptive states of affairs. (shrink)

Though legal positivism remains popular, HLA Hart’s version has fallen somewhat by the wayside. This is because, according to many, the central task of a theory of law is to explain the so-called ‘normativity of law’. Hart’s theory, it is thought, is not up to the task. Some have suggested modifying the theory accordingly. This paper argues that both Hart’s theory and the normativity of law have been misunderstood. First, a popular modification of Hart’s theory is considered and rejected. It (...) stems from a misunderstanding of Hart and his project. Second, a new understanding of the mysterious but often-mentioned ‘normativity of law’ is presented. Once we have dispelled some misunderstandings of Hart’s view and clarified the sense in which law is supposed to be normative, we see that Hart’s view, unmodified, is well suited to the task of explaining law’s normativity. (shrink)

This paper presents a series of arguments aimed at showing that, for an important subclass of social rules—non‐summary rules—no adequate metaphysical account has been given, and it tentatively suggests that no such account can be given. The category of non‐summary rules is an important one, as it includes the rules of etiquette, fashion, chess, basketball, California state law, descriptive English grammar, and so on. This paper begins with behavioristic accounts of the conditions for the existence of such rules, and proceeds (...) through progressively more complex accounts, all the way to what are labeled ‘normative attitude accounts,’ which are prima facie plausible and particularly popular. In each case it is argued that the type of account under consideration cannot explain the existence of the relevant type of social rule. (shrink)

This article examines how facial recognition technology reshapes the philosophical debate over the ethics of video surveillance. When video surveillance is augmented with facial recognition, the data collected is no longer anonymous, and the data can be aggregated to produce detailed psychological profiles. I argue that – as this non-anonymous data of people’s mundane activities is collected – unjust risks of harm are imposed upon individuals. In addition, this technology can be used to catalogue all who publicly participate in political, (...) religious, and socially stigmatised activities, and I argue that this would undermine central interests of liberal democracies. I examine the degree to which the interests of individuals and the societal interests of liberal democracies to maintain people’s obscurity while in public coincide with privacy interests, as popularly understood, and conclude that there is a practical need to articulate a novel right to obscurity to protect the interests of liberal democratic societies. (shrink)

The role of acetylcholinesterase (AChE) in neurotransmission is well known. But long before synapses are formed in vertebrates, AChE is expressed in young postmitotic neuroblasts that are about to extend the first long tracts. AChE histochemistry can thus be used to map primary steps of brain differentiation. Preceding an possibly inducing AChE in avian brains, the closely related butyrylcholinesterase (BChE) spatially fore-shadows AChE-positive cell areas and the course of their axons. In particular, before spinal motor axons grow, their corresponding rostral (...) sclerotomes and myotomes express BChE, and both their neuronal source and myotomal target cells express AChE. Since axon growth has been found inhibited by acetylcholine, it is postulated that both cholinetsreases can attract neurite growth cones by neutralizing the inhibitor. Thus, the early expression of both cholinesterases that is at least partially independent from classical cholinergic synaptogenesis, sheds new light on the developmental and medical significance of these enzymes. (shrink)

The most discussed theory of law of the twentieth century – HLA Hart’s theory from _The Concept of Law_ – is fundamentally _psychological_. It explains the existence of legal systems in terms of an attitude taken by legal officials: the internal point of view. Though much has been said about this attitude (what statements _express_ it, what it is _not_, how Hart _ought_ to have conceived of it, etc.), we nonetheless lack an adequate account of the attitude itself. This paper (...) presents and defends an account of the internal point of view and shows how, when understood as the account suggests, this attitude can play the several roles that Hartian positivists need it to play. (shrink)

The background concern of this paper is the well-rehearsed debate on the “theological turn” (or “veerings”) in French Phenomenology that was ignited by Dominique Janicaud some 25 years ago in his vociferous critique of several leading French thinkers. It also responds to subsequent contestations against Janicaud by numerous scholars defending these thinkers radicalising of phenomenology in their attempts to account for what Emanuel Levinas had “stirred up in the phenomenological field” by re-posing the question of the philosophical status of the (...) idea of God. What is pivotal to Janicaud in his exclusionary critique and drawing of phenomenological boundaries is to hold dearly to the method as Edmund Husserl intended. In doing so, only describable phenomena that appear (or are logically subtended to appear) provide the litmus for a bona fide phenomenology. In opening and broadening the method to include experiences of a transcendent, religious nature as the French thinkers do, orthodox Husserlian thinking places these projects into question. The purpose of this paper is to question these post-Husserlian thinkers with a more faithful reading of Husserl. I analyse three key areas to suggest a ‘divine limit’ to phenomena: first, the concept of “the phenomenon” as developed in Husserl’s project; second, the ‘status of the idea of God’ in Husserl’s writings; and third, the relevant philosophical discourse on God that emerges from the Janicaud-led debate through critical commentary on the phenomenology of the “inapparent”. As a consequence, God is argued to be a divine limit to Husserlian phenomenology, but not religious belief itself. (shrink)

Rachlin's thought-provoking analysis could be strengthened by greater openness to evolutionary interpretation and the use of the directed attention concept as a component of self-control. His contribution to the understanding of prosocial behavior would also benefit from abandoning the traditional (and excessively restrictive) definition of altruism.

Der erste Teil dieses Aufsatzes befasst sich mit der Tatsache, dass neben der Stammesgeschichte des Menschen (Phylogenese) und seiner je individuellen genetischen Ausstattung für seine Persönlichkeitsentwicklung besonders wichtig ist, dass sein Gehirn bei der Geburt noch unausgereift ist. In dieser Phase kommen Umwelteinflüsse (Lernen jeglicher Art) besonders stark zum Tragen, so daß die „Freiheit des Menschen“ hier wesentlich begründet wird. Soviel uns das Studium der Frühentwicklung des Gehirns (Ontogenese) über seine Organisation und seine Funktionen hat verstehen lassen, bleibt doch fraglich, (...) inwieweit die Hirnforschung uns in Fragen nach den seelisch-geistigen Fähigkeiten des Menschen, oder gar nach Gott und Gottesbildern weiterbringen kann. Im 2. Teil wird daher am Beispiel der Hirnfunktionen und der Frage nach dem Bewusstsein erläutert, warum menschliche Erkenntnisfähigkeit begrenzt ist. Die Naturwissenschaft behandelt Wenn-Dann-Fragen und liefert Gründe für das Dann. Sie kann jedoch weder Wesensfragen klären, noch den letzten Urgrund alles Seienden festmachen. Weil aber alles einen Grund haben muß, kann es ein absolutes Nichts niemals gegeben haben, oder geben. Daraus folgend wird im 3. Teil erläutert, dass es gerade rational Sinn macht, als Urgrund der Welt eine letzte Allmacht, also Gott zu denken. Religion kann demnach als höchste, weil freiheitlichste und damit menschlichste Leistung unseres Hirns verstanden werden. Die Evolution hat mit dem menschlichen Gehirn nicht nur die Stufe der Selbst-, sondern auch der Gottesreflexion erreicht. Dies könnte biologisch mit dem theologischen Begriff der Gottesebenbildlichkeit gemeint sein. (shrink)

Expressivism in logic is the view that logical vocabulary plays a primarily expressive role: that is, that logical vocabulary makes perspicuous in the object language structural features of inference and incompatibility (Brandom, 1994, 2008). I present a precise, technical criterion of expressivity for a logic (§2). I next present a logic that meets that criterion (§3). I further explore some interesting features of that logic: first, a representation theorem for capturing other logics (§3.1), and next some novel logical vocabulary for (...) expressing structural features of inference (§4). (shrink)

Physiologie und Struktur komplexer Gehirne lassen sich durch Betrachtung evolutions- und entwicklungsbiologischer Abläufe analysieren, was der Hirnforschung tiefe Einblicke bis zur molekularen Ebene erlaubt. In knappster Form werden grundlegende Aspekte der Stammes- und Individualentwicklung (Phylo- und Ontogenese) von Gehirnen im Tierreich beschrieben, bis hin zum menschlichen Gehirn, dessen Grobgliederung skizziert wird. Das Lernvermögen insbesondere von Kleinkindern ist aufgrund postnataler Hirnplastizität erklärbar. Systematische Unterschiede zwischen einzelnen Zellen und Neuronenverbänden sind für selbstorganisierende Bewußtseinsprozesse bedeutsam. Am Beispiel der stufenweisen visuellen Signalverarbeitung wird die (...) mögliche Wahrnehmung von Bildern diskutiert, um danach gängige Theorien zur Bewußtseinsfrage einander gegenüber zu stellen. Schließlich wird auf das Qualia-Problem eingegangen, was vom Autor als Unerklärbarkeit des Bewußtseinsinhalts und als Urfrage des Leib-Seele-Problems verstanden wird. Sie kann wohl auch durch modernste biologische Forschung nicht beantwortet werden. (shrink)

The normativity of meaning—introduced by Kripke in 1982, and the subject of active debate since the early 1990s—has been exclusively understood in terms of duty-imposing norms. But there are norms of another type, well-known within the philosophy of law: authority-conferring norms. Philosophers thinking and writing about the normativity of meaning—normativists, anti-normativists, and even Kripke himself—seem to have failed to consider the possibility that semantic norms are authority-conferring. I argue that semantic norms should be understood as having an authority-conferring structure, and (...) show how this allows normativism about meaning to escape the two most popular arguments against it. (shrink)

Biological research on race has often been seen as motivated by or lending credence to underlying racist attitudes; in part for this reason, recently philosophers and biologists have gone through great pains to essentially deny the existence of biological human races. We argue that human races, in the biological sense of local populations adapted to particular environments, do in fact exist; such races are best understood through the common ecological concept of ecotypes. However, human ecotypic races do not in general (...) correspond with 'folk' racial categories, largely because many similar ecotypes have multiple independent origins. Consequently, while human natural races exist, they have little or nothing in common with 'folk' races. (shrink)

Anlaß zum vorliegenden Artikel gab eine Tagung zum Thema „Gott-Geist-Gehirn“, bei der im Dialog zwischen Theologen und Neurowissenschaftlern Beziehungen zwischen diesen drei Begriffen diskutiert wurden. Aus biologischer Sicht sind es vor allem Hirnleistungen, welche uns spezifisch zum Menschen machen. Die Entstehung der Hirnstrukturen während der Embryonal- und Postnatalperiode wird im ersten Teil behandelt, deren Verständnis essentiell ist. Im zweiten Teil werden physiologische Fähigkeiten des menschlichen Gehirns am Beispiel des visuellen Systems in sehr verkürzter Weise dargestellt, um zu untersuchen, inwieweit physiologische (...) Erkenntnisse das Phänomen der Wahrnehmung bis hin zur Entstehung von Bewusstsein erklären können. Weil sich hier Verständnislücken auftun, die nach meinem Dafürhalten grundsätzlich und unlösbar sind (Qualia-Problem), komme ich schließlich zur Unvollständigkeit jeglicher naturwissenschaftlichen Weltsicht (unendliche Regresse) und die damit notwendige Annahme einer „Ur-Ursache“ dieser Welt, wie sie schon von Aristoteles im kosmologischen Gottesbeweis formuliert wurde. So führt diese Betrachtung zum Schluß, dass insbesondere Naturwissenschaftler einer Ur-Ursache bedürften (Gottesbedürftigkeit). (shrink)

Darwin´s Erkenntnis über die Abstammung der Arten durch Mutation und Selektion sind in aller Munde, dass aber darüber im Detail noch viel Unklarheit herrscht, ist weniger bekannt. Es sind Fortschritte der Entwicklungsbiologie, die erst seit wenigen Jahren uns molekulare Erklärungsmuster an die Hand geben, mit denen die Entstehung neuer Arten besser verständlich wird. Es handelt sich um die Aufklärung der Wirkungsweise von Genen und ihren molekularen Produkten, die während der embryonalen Entwicklung von Tier und Mensch dafür sorgen, daß der Organismus (...) sich normal entwickelt. Treten Veränderungen (Mutationen) in einem dieser Mastergene auf, so wird dies zur Missbildung oder gar zum Absterben des betreffenden Embryos führen. Aber in seltenen Fällen kann so auch eine neue Tierart begründet werden. Gerade im Darwin-Jahr werden die Lehrbücher zur Evolutionsbiologie um ein wesentliches Kapitel erweitert. Es ist mit EvoDevo überschrieben und will damit ausdrücken, daß Evolutionary Theory ohne Developmental Biology keinen Sinn macht. Die bisherigen Lücken im Verständnis des Evolutionsgeschehens und die neue Sicht von EvoDevo wird im Folgenden dargestellt werden. (shrink)

In this paper, I examine the ethics of nonviolent protest when a violent response is either foreseen or intended. One central concern is whether protesters, who foresee a violent response but persist, are provoking the violence and whether they are culpable for any eventual harms. A second concern is whether it is permissible to publicize the violent response for political advantage. I begin by distinguishing between two senses of the term provoke: a normative sense where a provocateur knowingly imposes an (...) unjustified risk of a violent response, and a descriptive sense where the respondent feels provoked. I argue that, when the risk of a violent response is justified, the protesters are not provocateurs but akin to nonculpable, entrapping agents who create an opportunity for the regime to respond with disproportionate violence. The regime’s response can disclose its brutality or criminality and this can be fairly publicized for political advantage. When nonviolent protesters create an unjustified risk of violence either because the injustice they oppose is insufficient to justify the risk of a violent response or because the risked harms are disproportionate with the likely political advantages derived from the protest, they are partially culpable provocateurs. However, I argue these partially culpable provocateurs can still permissibly publicize the disproportionate violence of the regime so as to shape public opinion. (shrink)

Twenty years have passed since Gould and Lewontin published their critique of ‘the adaptationist program’ – the tendency of some evolutionary biologists to assume, rather than demonstrate, the operation of natural selection. After the ‘Spandrels paper’, evolutionists were more careful about producing just-so stories based on selection, and paid more attention to a panoply of other processes. Then came reactions against the excesses of the anti-adaptationist movement, which ranged from a complete dismissal of Gould and Lewontin’s contribution to a positive (...) call to overcome the problems. We now have an excellent opportunity for finally affirming a more balanced and pluralistic approach to the study of evolutionary biology. (shrink)

Ratio Juris, Volume 34, Issue 4, Page 331-355, December 2021.

Das letzte halbe Jahrhundert hat einen unvergleichlichen Siegeszug der Molekularbiologie erlebt, zu dem die Genomik, die molekulare Zell- und Entwicklungsbiologie, die Epigenetik sowie Erkenntnisse der Stammzellbiologie als tragende Säulen beigetragen und die Biowissenschaften insgesamt in die sogenannte postgenomische Ära geführt haben. Anstelle eines verengten Blicks in den Kern der Zelle und seiner DNA hat sich das Visier von Biologen auf eine sich dynamisch verändernde Zellumgebung hin geöffnet. Wechselwirkungen zwischen molekularen, zellulären, organismischen bis hin zu ökologischen Hierarchieebenen, stets aufwärts und abwärts (...) interagierend (bottom-up und top-down), bestimmen das Bild postgenomischer Naturbetrachtung. Dieses erweiterte Gesichtsfeld führte einerseits weg von einem strikten Gen-gesteuerten Determinismus hin zu Systemdenken und zur Systembiologie. Zum anderen rückten auf diesem Weg wieder Lücken in der klassischen neodarwinistischen Lehre in den Fokus, die nach einer erweiterten Synthese der Standardlehre der Evolution rufen. So hat das neue Forschungsfeld Evo-Devo (Akronym für Evolutionary Developmental Biology) erstmals molekulare Mechanismen für die sprunghafte Entstehung von Merkmalen aufgezeigt, die die Grundlage für die Entstehung neuer Baupläne (Makroevolution) bildeten. (shrink)

Objective: This study aims to provide an in-depth knowledge of the perspectives of young adults on gender roles. There is a lack of literature in the appropriate age classes. -/- Methods: The study is descriptive in nature and includes 473 students. This research was conducted using a questionnaire and the Social Gender Perception Scale (SGPS) to collect data. -/- Results: It was determined that 52.4% of the study participants were female and 47.6% were male. 63% of the participants were affiliated (...) with the Faculty of Health Sciences, while the remainder were students from other faculties. The average SGPS score of the participants was 95.62±18.17, but this score varied based on socio-demographic variables. Specifically, being female, possessing an undergraduate degree or higher, studying in a health sciences faculty, and having a mother who completed primary school or higher were all linked to higher SGPS mean scores. Furthermore, statistical analysis revealed a significant difference between these groups (p<0.05). -/- Conclusion: It is imperative that parents are provided with educational programs aimed at fostering knowledge of social gender roles and cultivating egalitarian attitudes and viewpoints. It is important to strategically design and execute research endeavours aimed at ascertaining the perspectives and attitudes of parents of young individuals with respect to societal gender roles. (shrink)

Fiona Macpherson (2012) argues that various experimental results provide strong evidence in favor of the cognitive penetration of perceptual color experience. Moreover, she proposes a mechanism for how such cognitive penetration occurs. We argue, first, that the results on which Macpherson relies do not provide strong grounds for her claim of cognitive penetrability; and, second, that, if the results do reflect cognitive penetrability, then time-course considerations raise worries for her proposed mechanism. We base our arguments in part on several of (...) our own experiments, reported herein. (shrink)

Objective: Long-term C-arm fluoroscopy exposes medical personnel to substantial radiation doses. Preventing this exposure requires protective equipment and radiation safety. This study examined anesthesia students' using fluoroscopy and preventive knowledge. -/- Methods: This descriptive and cross-sectional study included 139 Vocational High School Anesthesia students. The "Healthcare Professional Knowledge of Radiation Protection" scale and a 13-question survey collected data. The scale was designed with a Likert scale and three sub-factors. If the total and sub-dimension item average score of the scale is (...) below 5, it indicates that the level of knowledge of radiation protection among medical personnel is low, and if it is above 5, it indicates that the level of knowledge is high. -/- Results: More than half of the students (59.8%) heard the radiation from the fluoroscopy device, the vast majority (82.7%) did not receive radiation protection training, 58.3% stayed away from the device while it was operating, and 70.5% stated that it is crucial to stay away from the device while it was operating. It was determined that there was a statistically significant difference (p<0.05) in the "Radiation Physics, Biology, and Radiation Usage Principles" sub-dimension of students who were male, in their second year of education, received radiation protection training, and offered reliable answers to a number of questions measuring their level of radiation knowledge. In addition, the research revealed a positive and highly significant correlation between the scale and its subdimensions. -/- Conclusion: Although the scale scores of the students who received radiation protection training and had a high level of radiation knowledge were substantially higher than those of the other students, the average score of the students was less than 5. This indicates that students have an inadequate understanding of radiation protection. To prevent the negative biological effects of radiation on the human body, it is necessary to conduct epidemiological research, educate health care professionals and anesthesiology students about the effects and processes of this radiation on human cells, and provide frequent training. Radiation, radiation's biological effects, and radiation protection should be included in health students' curricula. (shrink)

Die Frage nach der Vererbung von Eigenschaften bei Lebewesen beschäftigt den Menschen seit alters her: das ist Genetik. Auch lange schon beschäftigen sich Biologen mit der Frage, wie sich die vielen Tierarten im Laufe einer langen Stammesgeschichte herausbilden konnten: das ist Evolution. Wie wird Konstantes über Generationen bewahrt und Diverses/Neues eingeführt? Die überragenden Erfolge der Genetik haben uns im Glauben eingelullt, wir hätten diese Prozesse vollständig verstanden. Mit dem Aufkommen der so genannten Epigenetik kommen Grundlagen sowohl der Individual-, wie auch (...) der Stammesentwicklung jedoch wieder ins Schwanken. In diesem Artikel will ich einen kleinen Einblick in das Feld der Epigenetik und ihre gesellschaftliche Relevanz geben. (shrink)

Nach neodarwinistischem Verständnis der Evolution entstehen neue Organismen letztlich durch rein zufällige Mutationsprozesse auf genetischer Ebene. Ihre Überlebenschancen werden dann durch die jeweilig herrschende Umwelt begünstigt oder unterdrückt. Die Evolution ist demnach nur vom reinen Zufall geleitet. Neuere Einsichten aus Entwicklungsbiologie (EvoDevo) und Epigenetik haben unsere Sicht der Evolutionsabläufe jedoch deutlich erweitert. Dabei kommt der Umwelt eine lenkende Rolle zu, der reine Zufall verliert an Bedeutung. Damit lässt sich naturwissenschaftliches Verständnis wieder besser mit herkömmlichen Schöpfungsbildern versöhnen.

Never was dogmatic reductionism helpful in conceiving the phenomenon of life. The post-genomic era has made it clear that genes alone cannot explain the functioning of whole organisms. Already each cell represents a unique, non-recurring individual. Recent progress in developmental biology has conveyed new perspectives both on the makings of individual organisms (ontogeny), as on evolutionary change (Evo-Devo). The genome (the entirety of all genes) of an animal remains constant from fertilization onwards in each cell. The realization of genes requires (...) molecular environments, in particular pertinent to the cytoplasm of the unfertilized egg. Individuality of an organism therefore is not only determined by its genome, but is shaped through developmental processes (it needs time!). Organisms can only exist through mutual interplays with their respective (molecular and cellular) environments at all levels of organization. Thus, life can be conceived of as endless networks of communication, e.g. as a mutual continuum, connecting all individuals, all species and all generations within their given environments. Evolutionarily, nature does not select fitting genes, but rather viable traits. The presented concepts render it unlikely that it was genes that founded our living world, but rather that distinct environments shaped “genes” (of whatever chemical nature) which proved to be “life-suitable”. (shrink)

Molecular developmental biology has expanded our conceptions of gene actions, underpinning that embryonic development is not only governed by a set of specific genes, but as much by space–time conditions of its developing modules. Typically, formation of cellular spheres, their transformation into planar epithelia, followed by tube formations and laminations are modular steps leading to the development of nervous tissues. Thereby, actions of organising centres, morphogenetic movements, inductive events between epithelia, tissue polarity reversal, widening of epithelia, and all these occurring (...) orderly in space and time, are driving forces of emergent laminar neural tissues, e.g. the vertebrate retina. Analyses of self-organisational formation of retina-like 3D structures from dispersed cells under defined cell culture conditions demonstrate that not only particular genetic networks, but—at least as important—the applied culture conditions define phenotypes of emergent tissues. Such in vitro approaches allow assigning emerging tissue formation to ground-laying genetic networks separately from contributions by conditional constraints. (shrink)

Der Kugel als Grundbauform des Lebens begegnen wir im gesamten Organismenreich, angefangen von sphärischen einzelligen Lebewesen wie der Namibperle (Thiomargaritha namibiensis), einem großen marinen Bakterium, über kugelige, vielzellige Algen wie der Süßwasseralge Volvox, marinen Rippenquallen wie der Seestachelbeere (Pleurobrachia) und den frühen Entwicklungsstadien tierischer Vielzeller (Metazoa). Alle diese kugeligen Gestalten finden wir fast ausschließlich in wässrigem Milieu. An Land sind die Pflanzen hingegen generell langgestreckt. Tiere haben spätestens beim Auszug aus einer aquatischen Umgebung die Kugelform aufgegeben. Diese Beobachtung führt zur (...) Frage nach den grundlegenden Prinzipien der Bauplanevolution im Zusammenhang mit dem Landgang der Tiere und Pflanzen. Beim Landgang konnte auf bereits im aquatischen Milieu entwickelte Grundformen zurückgriffen werden. Bei den Pflanzen waren es die von Algen bekannten Zellfäden, aus denen die bipolare Langform hervorging. Mit dem einen Ende dem mineralischen Untergrund verhaftet und mit dem anderen in die Atmosphäre reichend, schufen sie die Grundlagen für terrestrische Tiere. Der Schritt ans Land vollzog sich bei Tieren mehrfach und ging von einer größeren Zahl von Bauplänen aus. Wie die evolutionäre Entwicklungsbiologie (EvoDevo) nahelegt, gingen diese auf kleine Abwandlungen in der Embryonalentwicklung zurück, die in kurzen Zeiträumen große Entwicklungsschritte (Makrosprünge) möglich machen. Entsprechend rasch konnten sich die Tiere auch an terrestrische Bedingungen anpassen. (shrink)

Berge von brennenden Tieren, Bilder vom „Keulen“, Bilder vom geklonten Menschen. Aber auch Euphorisches: nach der Aufklärung des menschlichen Genoms schöpfen Krebs- und AIDS-Kranke, Querschnittsgelähmte und Alzheimer-Patienten neue Hoffnung. Bilder auch von Börsenkursen: vom neuen Markt der Informations- und Biotechnologien hängt unsere ökonomische Zukunft ab. Hinter allem stecken die „Life Sciences“, und oft wird man mit schrägem Blick gefragt, was das für Leute sind, diese Bio- bzw. Lebenswissenschaftler? Die Frage nach den Möglichkeiten und dem wahren Wert des biomedizinischen Fortschritts, nach (...) seiner Kontrolle, nach seiner Verantwortung, nach seiner gesellschaftlichen Bindung wird lauter. (shrink)

Bei der Suche nach dem rätselhaften Ursprung des Phänomens „Leben“ wird hier zunächst die zelluläre Ebene betrachtet. Im Grundaufbau zeigen alle Zellen viel Konstantes, aber gleichzeitig stellt jede Zelle ein einmaliges Individuum dar. Leben von Zellen gibt es nur als gegenseitiges Wechselspiel mit ihrer jeweiligen Umwelt. Das Genom (die Gesamtheit aller Gene) bleibt ab der Befruchtung in jeder Zelle eines Individuums konstant. Aber auch die Verwirklichung der Gene braucht eine „molekulare Umwelt“, besonders die vom Muttertier vorbereitete Umwelt im Zytoplasma des (...) Eies. Individualität eines Organismus (z.B. des Menschen) wird also nicht allein vom Genom festgelegt, sondern ist durch Entwicklungsprozesse bedingt (braucht Zeit!). „Leben“ kann (muß?) somit begriffen werden als ein wechselseitiges Kontinuum, welches alle Individuen, alle Spezies und alle Generationen miteinander und ihren Umwelten verbindet. Wie phylogenetisch betrachtet die allererste Zelle aus abiotischen Umständen entstehen konnte, wird hier nicht behandelt. Das Gesagte legt allerdings nahe, dass es nicht Gene waren, die sich eine belebte Welt erschufen, sondern bestimmte (Um-)Welten „erschufen“ sich Gene, die „lebenstauglich“ waren. (shrink)

Seit der Aufklärung versucht der Mensch, Gott abzuschaffen. Dabei fällt der Zufälligkeit, und damit auch der Ziellosigkeit in der darwinistischen Sicht der Evolution besonderes Gewicht zu. Diese weithin akzeptierten Dogmen stehen diametral gegen jahrtausendealte Vorstellungen, die letztlich in allen Kulturen und Religionen hervorgebracht wurden, daß die Natur eine Schöpfung Gottes sei, in der der Mensch das höchste, Gott-ebenbildliche Wesen sei. Nach Erkenntnissen der klassischen Genetik schienen Gene an die Stelle von Gott getreten zu sein: sie haben absolute Gewalt und beherrschen (...) die belebte Natur. Sie haben je einen eindeutigen Befehl, sind unbeugsam und gerecht, wie Gott im AT. Das Produkt Mensch ist nur einer ihrer zahllosen Spielbälle, existiert vorübergehend, ein Zigeuner in einer verlassenen Ecke des Kosmos (Monod, 1992). Diese neodarwinistische Sicht, die nicht zuletzt zum Niedergang der Kirchen bei uns beiträgt, wird von neuen Erkenntnissen der Entwicklungsbiologie (EvoDevo) infrage gestellt. (shrink)

The works of the later Wittgenstein resonate with aspects of the pragmatist tradition in American philosophy. Davidson’s work is similarly informed. We argue that because of their association with the pragmatist tradition, their work can be put to use by philosophers interested in social justice issues, including, for example, feminism, and critical race theory. Philosophers concerned with social justice continue to struggle between the extremes of an untenable foundationalism and a radical relativism. Given their holistic understanding of knowledge, meaning and (...) communication, the work of Wittgenstein and Davidson is particularly suited to dissolving the foundationalist/relativist dichotomy. We explore how this and other features of their work facilitates philosophy for social change. (shrink)